Kuroda C, Mihara N, Hosomi N, Inoue E, Fujita M, Ohigashi H, Ishikawa O, Nakaizumi A, Ishiguro S
Department of Diagnostic Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
Acta Radiol. 1998 Mar;39(2):138-43. doi: 10.1080/02841859809172167.
To compare the diagnostic efficacy of pancreatic pharmacoangiographic CT using angiotensin II with conventional angiographic CT.
Eighteen patients with space-occupying pancreatic disease were examined in this study. Pharmacoangiographic CT was performed with a 1-3 micrograms/6-ml solution of angiotensin II injected through a catheter into the celiac artery during spiral CT.
In 17 of the 18 (94%) patients, the area of pancreatic parenchymal enhancement was the same or larger at pharmacoangiographic CT than at conventional angiographic CT. The attenuation value of the pancreatic parenchyma was significantly increased at pharmacoangiographic CT (p = 0.0010). Although the attenuation value of tumors was also increased on images obtained after the injection of angiotensin II, the tumor-to-pancreas contrast was significantly greater at pharmacoangiographic CT (p = 0.0479). The mean differences in attenuation between tumor and pancreas at angiographic CT with and without angiotensin II were respectively 182 HU and 115 HU.
Pharmacoangiographic CT with angiotensin II proved superior to conventional angiographic CT in the diagnosis of pancreatic disease. We therefore recommend it as a supplementary technique at the angiographic examination of patients with suspected pancreatic tumor.
比较使用血管紧张素 II 的胰腺药物血管造影 CT 与传统血管造影 CT 的诊断效能。
本研究对 18 例患有胰腺占位性疾病的患者进行了检查。在螺旋 CT 扫描期间，通过导管将 1 - 3 微克/6 毫升的血管紧张素 II 溶液注入腹腔动脉，进行药物血管造影 CT 检查。
18 例患者中的 17 例（94%），药物血管造影 CT 显示的胰腺实质强化面积与传统血管造影 CT 相同或更大。药物血管造影 CT 时胰腺实质的衰减值显著增加（p = 0.0010）。尽管注射血管紧张素 II 后获得的图像上肿瘤的衰减值也有所增加，但药物血管造影 CT 时肿瘤与胰腺的对比度显著更高（p = 0.0479）。在使用和未使用血管紧张素 II 的血管造影 CT 中，肿瘤与胰腺之间的平均衰减差异分别为 182 HU 和 115 HU。
使用血管紧张素 II 的药物血管造影 CT 在胰腺疾病诊断中被证明优于传统血管造影 CT。因此，我们建议将其作为疑似胰腺肿瘤患者血管造影检查的辅助技术。
