Woodburn K R, Rumley A, Love J G, Murray G D, Lowe G D
Vascular Surgery Unit, Glasgow Royal Infirmary, UK.
Br J Surg. 1998 Mar;85(3):351-4. doi: 10.1046/j.1365-2168.1998.00613.x.
Occlusive arterial disease causes alterations in blood rheology and levels of potential thrombotic and fibrinolytic mediators. The aim of this study was to investigate the effect of graft materials on these parameters in patients undergoing successful infrainguinal revascularization.
Some 186 consecutive infrainguinal grafts were observed for 12 months. Venous blood was sampled before operation and at 3, 6, and 12 months after surgery. Samples were assayed for thrombotic and rheological parameters. An area under the curve analysis was used to compare the effects of vein and synthetic grafting on these parameters in 99 patients whose grafts remained patent and free from stenosis.
Plasma levels of fibrin degradation products were significantly higher in patients with synthetic grafts (n = 46) than in those with autogenous vein grafts (n = 53) (median 274 versus 150 ng/ml; P < 0.001). There were no significant differences in plasma fibrinogen or any other parameters between the two groups.
Patients with a synthetic infrainguinal graft have a higher fibrin turnover than those with a vein graft. Further studies are required to determine whether this increase in fibrin turnover is an essential requirement to maintain patency of a synthetic infrainguinal graft.
闭塞性动脉疾病会导致血液流变学以及潜在血栓形成和纤溶介质水平发生改变。本研究旨在调查移植材料对成功进行股动脉以下血管重建术患者的这些参数的影响。
对连续186例股动脉以下移植患者进行了12个月的观察。在手术前以及术后3、6和12个月采集静脉血样。对样本进行血栓形成和流变学参数检测。采用曲线下面积分析比较99例移植血管通畅且无狭窄患者中静脉移植和人工血管移植对这些参数的影响。
人工血管移植患者（n = 46）血浆纤维蛋白降解产物水平显著高于自体静脉移植患者（n = 53）（中位数分别为274和150 ng/ml；P < 0.001）。两组之间血浆纤维蛋白原或任何其他参数均无显著差异。
人工股动脉以下移植患者的纤维蛋白周转高于静脉移植患者。需要进一步研究以确定纤维蛋白周转的增加是否是维持人工股动脉以下移植血管通畅的必要条件。
