Hurni M A, Gerbig A W, Braathen L R, Hunziker T
Dermatological Clinic, University of Berne, Inselspital, Berne, Switzerland.
Dermatology. 1997;195(4):325-8. doi: 10.1159/000245981.
The etiology of Wells' syndrome or eosinophilic cellulitis is unknown. Various triggering factors, such as myeloproliferative disorders, lymphoma, infections/infestations, insect bites and drugs have been reported. In 1979, Wells was the first who pointed out some common features of eosinophilic cellulitis and skin lesions in toxocariasis.
We report 2 patients who exhibited the characteristic clinical and histological features of Wells's syndrome together with elevated antibody titers to the excretory-secretory antigen of Toxocara canis.
In both patients, the skin lesions disappeared after oral albendazole treatment and no recurrences were observed. The clinical response was followed by a normalization of the Toxocara antibody titer. In contrast, a patient with eczematoid skin lesions, eosinophilia and an elevated Toxocara antibody titer did not benefit from albendazole treatment despite serological normalization.
Taken together, these cases lend support to a causal relationship of Toxocara in selected patients with Wells' syndrome.
威尔斯综合征或嗜酸性粒细胞性蜂窝织炎的病因尚不清楚。已报道了多种触发因素，如骨髓增殖性疾病、淋巴瘤、感染/寄生虫感染、昆虫叮咬和药物。1979年，威尔斯首次指出嗜酸性粒细胞性蜂窝织炎与弓蛔虫病皮肤病变的一些共同特征。
我们报告2例表现出威尔斯综合征特征性临床和组织学特征，同时犬弓蛔虫排泄分泌抗原抗体滴度升高的患者。
2例患者口服阿苯达唑治疗后皮肤病变消失，未观察到复发。临床症状缓解后，弓蛔虫抗体滴度恢复正常。相比之下，1例患有湿疹样皮肤病变、嗜酸性粒细胞增多和弓蛔虫抗体滴度升高的患者，尽管血清学指标恢复正常，但阿苯达唑治疗无效。
综上所述，这些病例支持弓蛔虫与部分威尔斯综合征患者之间存在因果关系。
