Melski J W
Department of Dermatology and Cutaneous Surgery, Saint Joseph's Hospital, Marshfield, Wisconsin.
Dermatol Clin. 1990 Apr;8(2):287-93.
Wells' syndrome is an idiopathic, recurrent, inflammatory dermatosis that appears to result from "dysregulated" tissue eosinophilia. The disease usually remits, and the course is benign despite occasional constitutional symptoms. The histology includes flame figures produced by the deposition of major basic protein on collagen bundles by eosinophils. Flame figures are not unique to Wells' syndrome. The term "eosinophilic cellulitis" is ambiguous, since it has been used for both Wells' syndrome and any eosinophil infiltrate with flame figures. Clinical descriptions suggest that insect bites may precipitate the initial or subsequent episodes of some cases. Insects may also be the vectors for parasitic diseases that should be considered in the differential diagnosis. Drugs and infections, including tinea, may also precipitate episodes. Wells' syndrome may be superimposed on chronic urticaria or may complicate the course of a myeloproliferative disease. The relationship of Wells' syndrome to other idiopathic diseases with eosinophilia is unknown.
韦尔斯综合征是一种特发性、复发性炎症性皮肤病，似乎是由“失调”的组织嗜酸性粒细胞增多引起的。该病通常会缓解，尽管偶尔有全身症状，但病程呈良性。组织学表现包括嗜酸性粒细胞将主要碱性蛋白沉积在胶原束上所产生的火焰状图形。火焰状图形并非韦尔斯综合征所特有。“嗜酸性粒细胞性蜂窝织炎”这一术语具有歧义性，因为它既用于韦尔斯综合征，也用于任何伴有火焰状图形的嗜酸性粒细胞浸润。临床描述表明，昆虫叮咬可能会引发某些病例的初始发作或后续发作。昆虫也可能是寄生虫病的传播媒介，在鉴别诊断中应予以考虑。药物和感染，包括癣，也可能引发发作。韦尔斯综合征可能叠加在慢性荨麻疹之上，或者使骨髓增殖性疾病的病程复杂化。韦尔斯综合征与其他伴有嗜酸性粒细胞增多的特发性疾病之间的关系尚不清楚。
