Ammirati C T, Mann C, Hornstra I K
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Dermatology. 1997;195(4):344-8. doi: 10.1159/000245985.
Multiple eruptive dermatofibromas (MEDF) are rare and their etiology is unknown. An association with immunosuppression has led to the speculation that they are the result of an abortive immunoreactive process. In the literature, there have been 5 isolated case reports of multiple dermatofibromas and human immunodeficiency virus (HIV) infection. Three of these cases had other immune modulators present (i.e. prednisone, systemic lupus erythematosus, alpha-interferon, UVB phototherapy). The other 2 cases had disseminated mycobacteriosis.
A series of 3 men with HIV infection and MEDF is described. In contrast to previous case reports, our patients did not have other immune modulators besides HIV infection nor did they have disseminated mycobacteriosis.
This series lends support to the speculation that MEDF may be associated with immunosuppression. Further study is needed to delineate the exact mechanism for this relationship. These patients presented within a 4-month period and illustrate the frequency at which MEDF may be seen in the HIV-positive population. As clinicians who care for patients with HIV infection, it is important to be aware that MEDF may be seen in this immunosuppressed population.
多发性发疹性皮肤纤维瘤（MEDF）较为罕见，其病因不明。与免疫抑制的关联引发了一种推测，即它们是免疫反应过程失败的结果。在文献中，有5例多发性皮肤纤维瘤与人类免疫缺陷病毒（HIV）感染的孤立病例报告。其中3例伴有其他免疫调节剂（如泼尼松、系统性红斑狼疮、α干扰素、紫外线B光疗）。另外2例患有播散性分枝杆菌病。
描述了3例患有HIV感染和MEDF的男性病例。与之前的病例报告不同，我们的患者除HIV感染外没有其他免疫调节剂，也没有播散性分枝杆菌病。
该系列病例支持了MEDF可能与免疫抑制相关的推测。需要进一步研究来阐明这种关系的确切机制。这些患者在4个月内就诊，说明了在HIV阳性人群中MEDF的出现频率。作为照顾HIV感染患者的临床医生，认识到在这个免疫抑制人群中可能出现MEDF很重要。
