病毒对抗细胞凋亡的斗争。
The fight of viruses against apoptosis.
作者信息
Tschopp J, Thome M, Hofmann K, Meinl E
机构信息
Institute of Biochemistry, BIL Research Center, Epalinges, Switzerland.
出版信息
Curr Opin Genet Dev. 1998 Feb;8(1):82-7. doi: 10.1016/s0959-437x(98)80066-x.
PMID:9529610
Abstract
The induction of apoptosis of virus-infected cells is an important host defense mechanism against invading pathogens. Some viruses express anti-apoptotic proteins that efficiently block apoptosis induced by death receptors or in response to stress signaled through mitochondria. Viral interference with host cell apoptosis leads to enhanced viral replication and may promote cancer.
摘要
诱导病毒感染细胞凋亡是宿主抵御入侵病原体的一种重要防御机制。一些病毒表达抗凋亡蛋白，可有效阻断死亡受体诱导的凋亡或对通过线粒体发出的应激信号作出反应的凋亡。病毒对宿主细胞凋亡的干扰会导致病毒复制增强，并可能促进癌症发生。
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