Chang K H, Ha J W, Chung N S, Cho S Y
Department of Cardiology Division, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1998 Feb;39(1):61-6. doi: 10.3349/ymj.1998.39.1.61.
Left ventricular systolic function in hypertrophic cardiomyopathy (HCMP) does not usually deteriorate even in the end stage of the disease. However, occasionally cases of HCMP progress to a similar form of dilated cardiomyopathy (DCMP) with a decreased systolic function and dilated left ventricle. We report two cases of HCMP which progressed to DCMP during follow-up. Our cases have been documented by serial M-mode echocardiography which shows a prominent decrease in the left ventricular systolic function and a chamber enlargement of the left ventricle. There are various explanations of the pathogenesis of the functional and morphological myocardial deterioration of HCMP progressing to DCMP, and more cases should be studied to determine the pathogenesis and prevention of this end-stage feature of HCMP.
肥厚型心肌病（HCMP）患者的左心室收缩功能即使在疾病终末期通常也不会恶化。然而，偶尔会有HCMP病例进展为类似形式的扩张型心肌病（DCMP），伴有收缩功能下降和左心室扩张。我们报告两例HCMP在随访期间进展为DCMP的病例。我们的病例通过连续M型超声心动图记录，显示左心室收缩功能显著下降和左心室腔扩大。对于HCMP进展为DCMP的心肌功能和形态学恶化的发病机制有多种解释，需要研究更多病例以确定这种HCMP终末期特征的发病机制和预防方法。
