脂肪母细胞瘤：1例伴有t(7;8)(q31;q13)的病例。
Lipoblastoma: a case with t(7;8)(q31;q13).
作者信息
Panarello C, Rosanda C, Morerio C, Russo I, Dallorso S, Gambini C, Ricco A S, Storlazzi T, Archidiacono N, Rocchi M
机构信息
Department of Pediatric Hematology/Oncology, Giannina Gaslini Institute, Genova, Italy.
出版信息
Cancer Genet Cytogenet. 1998 Apr 1;102(1):12-4. doi: 10.1016/s0165-4608(97)00272-0.
Lipoblastoma is a rare benign adipose tumor which, in all of the cases so far described, presents an involvement of chromosome 8 in the region 8q11-13. We hereby report the results of the second case of lipoblastoma studied by fluorescence in situ hybridization (FISH), in a 13-month-old boy. An abnormal karyotype 46,XY,t(7;8)(q31;q13) was found in 90% of the metaphases examined, in agreement with the previously reported observations. We suggest the region 8q11-13 may contain a relevant locus for lipoblastoma origin.
脂肪母细胞瘤是一种罕见的良性脂肪肿瘤，在迄今为止描述的所有病例中，均显示8号染色体8q11 - 13区域受累。我们在此报告第二例通过荧光原位杂交（FISH）研究的脂肪母细胞瘤病例，患者为一名13个月大的男孩。在所检查的90%的中期分裂相中发现了异常核型46,XY,t(7;8)(q31;q13)，这与先前报道的观察结果一致。我们认为8q11 - 13区域可能包含与脂肪母细胞瘤起源相关的基因座。
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