[S-腺苷同型半胱氨酸和S-腺苷甲硫氨酸类似物的新合成方法]
[New syntheses of S-adenosylhomocysteine and S-adenosylmethionine analogs].
作者信息
Legraverend M, Michelot R
出版信息
Biochimie. 1976;58(6):723-9. doi: 10.1016/s0300-9084(76)80397-5.
PMID:953062
Abstract
With the aim of studying analogues of S adenosyl homocysteine and S adenosyl methionine as potential inhibitors of methyl-transferases, we describe the syntheses of such analogues, in which either the amino-acid chain is replaced by various aliphatic radicals of the N 6 amino group of adenine is substituted.
摘要
为了研究S-腺苷高半胱氨酸和S-腺苷甲硫氨酸的类似物作为甲基转移酶的潜在抑制剂，我们描述了此类类似物的合成方法，其中腺嘌呤的N6氨基的氨基酸链被各种脂肪族基团取代，或者腺嘌呤的N6氨基被取代。
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[New syntheses of S-adenosylhomocysteine and S-adenosylmethionine analogs].[S-腺苷同型半胱氨酸和S-腺苷甲硫氨酸类似物的新合成方法]
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 4. Further modifications of the amino and base portions of S-adenosyl-L-homocysteine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。4. S-腺苷-L-高半胱氨酸氨基和碱基部分的进一步修饰。
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引用本文的文献
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Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes.S-腺苷同型半胱氨酸和S-3-去氮腺苷同型半胱氨酸对小鼠淋巴细胞中环磷酸腺苷代谢的调节作用
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5639-43. doi: 10.1073/pnas.77.10.5639.
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Binding capacities of various analogues of S-adenosyl-L-homocysteine to protein methyltransferase II from human erythrocytes.S-腺苷-L-高半胱氨酸的各种类似物对人红细胞中蛋白甲基转移酶II的结合能力。
Experientia. 1979 Aug 15;35(8):1007-9. doi: 10.1007/BF01949909.
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