Roperto F, Langella M, Oliva G, Restucci B, Varricchio E, Dallai R
Department of Veterinary Pathology, Federico II University, Naples, Italy.
J Submicrosc Cytol Pathol. 1998 Jan;30(1):65-9.
Specimens of tracheal mucosa were obtained from ten adult apparently healthy small ruminants (five goats and five sheep) both by a fibre optic endoscope and in a slaughterhouse. Ultrastructurally, a total of 50,000 cilia were examined. Pathological cilia were found in all examined subjects. The prevalence of compound cilia showed a range of 0.3% to 3%. Intracytoplasmic and swollen cilia ranged from 0.2% to 0.5%. The microtubular pattern was examined in 4,000 cross-sectioned cilia and an abnormal pattern was found in 5-7%. Microtubular defects involved both peripheral and central doublets, being peripheral abnormalities the prevailing ones. A central plug of electron dense material was observed in 2-3% of the examined basal bodies. Rare basal bodies characterized by an abnormal spatial configuration were also shown. Freeze fracture studies revealed a ciliary necklace composed of 4 to 5 rows of intramembrane particles.
通过纤维光学内窥镜并在屠宰场从十只成年貌似健康的小反刍动物（五只山羊和五只绵羊）获取气管黏膜样本。在超微结构上，共检查了50,000根纤毛。在所有检查对象中均发现了病理性纤毛。复合纤毛的患病率在0.3%至3%之间。胞质内和肿胀的纤毛在0.2%至0.5%之间。在4000根横切纤毛中检查了微管模式，发现5%-7%存在异常模式。微管缺陷涉及外周和中央双联体，外周异常占主导。在2%-3%的检查基体中观察到电子致密物质的中央栓。还显示了以异常空间构型为特征的罕见基体。冷冻断裂研究揭示了由4至5排膜内颗粒组成的纤毛项链。
