Japaridze G, Kvernadze D, Geladze T, Kevanishvili Z
Institute of Clinical and Experimental Neurology, Tbilisi, Georgia.
Seizure. 1997 Dec;6(6):449-56. doi: 10.1016/s1059-1311(97)80019-2.
Auditory brainstem responses (ABRs), middle-latency responses (MLRs), and slow cortical potentials (SCPs) have been recorded in patients with partial epilepsy previously untreated by anticonvulsants. Peak latencies, interpeak intervals, and amplitudes were estimated and the mean group values were compared with the respective data in age- and gender-matched healthy individuals. Neither ABRs nor MLRs in the patients differed significantly from those in the control group. Conversely, the SCP characteristics demonstrated regular differences: the P2 peak latency in the patients was prolonged and both the P1N1 and N1P2 amplitudes were increased. Considering the mechanisms of the ABR and MLR, it has been suggested that the specific structures of central auditory pathway up to the primary cortex do not play any essential role in the pathogenesis of partial epilepsy. Furthermore, it is speculated that the SCP-generating cortical areas, being primarily of non-specific qualities, are intimately involved in the mechanisms of epilepsy.
在未经抗惊厥药物治疗的部分性癫痫患者中记录了听性脑干反应（ABR）、中潜伏期反应（MLR）和慢皮层电位（SCP）。估计了峰潜伏期、峰间间期和波幅，并将平均组值与年龄和性别匹配的健康个体的相应数据进行比较。患者的ABR和MLR与对照组相比均无显著差异。相反，SCP特征显示出规律性差异：患者的P2峰潜伏期延长，P1N1和N1P2波幅均增加。考虑到ABR和MLR的机制，有人提出，直至初级皮层的中枢听觉通路的特定结构在部分性癫痫的发病机制中不发挥任何重要作用。此外，推测产生SCP的皮层区域主要具有非特异性性质，与癫痫机制密切相关。
