Colonna M, Samaridis J, Cella M, Angman L, Allen R L, O'Callaghan C A, Dunbar R, Ogg G S, Cerundolo V, Rolink A
Basel Institute for Immunology, Switzerland.
J Immunol. 1998 Apr 1;160(7):3096-100.
Leukocyte activation can be negatively regulated by inhibitory receptors specific for MHC class I molecules. While one inhibitory receptor, Ig-like transcript 2 (ILT2), is expressed by all lymphoid and myelomonocytic cell types, other receptors display a more selective tissue distribution. Here we characterize an inhibitory receptor, termed ILT4, which is selectively expressed in monocytes, macrophages, and dendritic cells (DCs), binds classical class I molecules and the nonclassical class I molecules HLA-G, and transduces negative signals that can inhibit early signaling events triggered by stimulatory receptors. ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity.
白细胞活化可被MHC I类分子特异性抑制性受体负调控。虽然一种抑制性受体，即免疫球蛋白样转录物2（ILT2），在所有淋巴细胞和髓单核细胞类型中均有表达，但其他受体表现出更具选择性的组织分布。在此，我们对一种名为ILT4的抑制性受体进行了表征，它在单核细胞、巨噬细胞和树突状细胞（DC）中选择性表达，结合经典I类分子和非经典I类分子HLA - G，并转导可抑制刺激性受体触发的早期信号事件的负信号。ILT4可能控制髓单核细胞介导的炎症反应和细胞毒性，并可能调节其抗原呈递功能，使免疫反应聚焦于微生物挑战并避免自身反应性。
