Rossol R, Dobmeyer J M, Dobmeyer T S, Klein S A, Rossol S, Wesch D, Hoelzer D, Kabelitz D, Helm E B
Department of Internal Medicine III, University Hospital, Frankfurt, Germany.
Br J Haematol. 1998 Mar;100(4):728-34. doi: 10.1046/j.1365-2141.1998.00630.x.
Dysregulation of T-cell receptor (TCR) alphabeta bearing lymphocytes and an increase in Vdelta1+ gammadelta T cells are typical features of HIV-1 infection. However, the role of gammadelta T cells remains unclear. Therefore, peripheral blood mononuclear cells (PBMC) of 103 HIV-1-infected patients were investigated with respect to expression of Vdelta1. These results were compared to the Vdelta1 expression of bone marrow mononuclear cells (BMMC). In contrast to healthy controls, Vdelta1+ cells dominated among both PBMC and BMMC in HIV-1-infected patients. Analysis of the coexpression of CD25, CD8, HLA-DR and CD45RO revealed a high prevalence of Vdelta1/CD45RO and Vdelta1/HLA-DR double-positive PBMC only in HIV-1-infected patients but not in healthy donors. Furthermore, analysis of the gammadelta TCR repertoire in patients infected with hepatitis B virus, hepatitis C virus, herpes simplex virus (HSV)-1 and HSV-2 showed that the selective enhancement of Vdelta1+ cells was restricted to HIV infection and not observed in other virus diseases. Our data provide further support for the involvement of gammadelta T cells in immunosuppression and progression of HIV infection.
携带αβ型T细胞受体（TCR）的淋巴细胞失调以及Vδ1 + γδT细胞增加是HIV-1感染的典型特征。然而，γδT细胞的作用仍不清楚。因此，对103例HIV-1感染患者的外周血单个核细胞（PBMC）进行了Vδ1表达方面的研究。并将这些结果与骨髓单个核细胞（BMMC）的Vδ1表达进行比较。与健康对照相比，在HIV-1感染患者的PBMC和BMMC中，Vδ1 +细胞均占主导地位。对CD25、CD8、HLA-DR和CD45RO共表达的分析显示，仅在HIV-1感染患者而非健康供体中，Vδ1/CD45RO和Vδ1/HLA-DR双阳性PBMC的比例很高。此外，对感染乙型肝炎病毒、丙型肝炎病毒、单纯疱疹病毒（HSV）-1和HSV-2的患者的γδTCR库分析表明，Vδ1 +细胞的选择性增强仅限于HIV感染，在其他病毒疾病中未观察到。我们的数据为γδT细胞参与HIV感染的免疫抑制和进展提供了进一步支持。
