Hiernaux J, Babloyantz A
Biosystems. 1976 Jul;8(2):51-6. doi: 10.1016/0303-2647(76)90008-3.
A model for a prebiotic polymer synthesis in a gradient of monomer is presented. In the absence of mutations the synthesis of the polymer proceeds in the region where the monomer concentration is the highest. However if a favorable mutation occurs, the latter accumulates in the high concentration zone and the initial polymer is restricted to a poorer monomer concentration region.