Stipancić I, Zarković N
Klinika za kirurgiju Medicinskog fakulteta Sveucilista u Zagrebu.
Lijec Vjesn. 1997 Nov;119(10):279-90.
Severe accidental trauma often causes an immunosuppression accompanied by infection and sepsis which may be fatal. Furthermore, elective surgery could also cause dysfunction of the immune system. While physiopathological mechanisms of such posttraumatic immune system dysfunctions are still not sufficiently understood, the scope of research interest is focused particularly on the cytokine network and, recently, on the "nonspecific" mediators of oxidative stress. In this article some novel findings about the dysfunction of the immune system caused by trauma, including surgical injury, are briefly summarized, and the involvement of oxidative stress in these changes is emphasized.
严重的意外创伤常导致免疫抑制，并伴有感染和败血症，这可能是致命的。此外，择期手术也可能导致免疫系统功能障碍。虽然此类创伤后免疫系统功能障碍的生理病理机制仍未得到充分了解，但研究兴趣的范围尤其集中在细胞因子网络，以及最近对氧化应激的“非特异性”介质的研究。本文简要总结了一些关于创伤（包括手术损伤）导致免疫系统功能障碍的新发现，并强调了氧化应激在这些变化中的作用。
