一种具有蛋白质合成抑制作用的抗真菌抗生素（GR135402）的分离与特性鉴定
Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition.
作者信息
Kinsman O S, Chalk P A, Jackson H C, Middleton R F, Shuttleworth A, Rudd B A, Jones C A, Noble H M, Wildman H G, Dawson M J, Stylli C, Sidebottom P J, Lamont B, Lynn S, Hayes M V
机构信息
Glaxo Wellcome Research and Development, Hertfordshire, UK.
出版信息
J Antibiot (Tokyo). 1998 Jan;51(1):41-9. doi: 10.7164/antibiotics.51.41.
A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of activity included C. albicans and Cryptococcus neoformans but not some other Candida species or Aspergillus species. Therapeutic efficacy in a mouse model of systemic candidosis was attained following parenteral dosing.
一种新型抗真菌抗生素GR135402已从腐败色串孢的发酵液中分离出来，它能抑制白色念珠菌中的蛋白质合成，但对兔网织红细胞无此作用。其活性谱包括白色念珠菌和新型隐球菌，但不包括其他一些念珠菌属或曲霉属物种。经肠胃外给药后，在系统性念珠菌病小鼠模型中取得了治疗效果。
Zotero 插件