Differential effect of leflunomide on concordant xenogeneic islet graft rejection and recurrence of autoimmune diabetes.
作者信息
Guo Z, Mital D, Shen J, Chong A S, Tian Y, Foster P, Sankary H, McChesney L, Jensik S C, Williams J W
机构信息
Department of General Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA.
出版信息
Transplant Proc. 1998 Mar;30(2):463-4. doi: 10.1016/s0041-1345(97)01357-2.
PMID:9532129
Abstract
摘要
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Differential effect of leflunomide on concordant xenogeneic islet graft rejection and recurrence of autoimmune diabetes.
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Immunosuppression preventing concordant xenogeneic islet graft rejection is not sufficient to prevent recurrence of autoimmune diabetes in nonobese diabetic mice.免疫抑制可防止协调性异种胰岛移植排斥反应，但不足以防止非肥胖糖尿病小鼠自身免疫性糖尿病的复发。
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Immunotherapy with nondepleting anti-CD4 monoclonal antibodies but not CD28 antagonists protects islet graft in spontaneously diabetic nod mice from autoimmune destruction and allogeneic and xenogeneic graft rejection.使用非耗竭性抗CD4单克隆抗体而非CD28拮抗剂进行免疫治疗，可保护自发性糖尿病nod小鼠的胰岛移植免受自身免疫破坏以及同种异体和异种移植排斥。
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Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection.来氟米特和环孢素联合免疫抑制可预防猪胰岛移植至大鼠的异种移植排斥反应。
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