Carlsen K H, Halvorsen R, Pettersen M, Carlsen K C
Voksentoppen Center of Asthma, Allergy and Chronic Lung Diseases in Children, Oslo, Norway.
Pediatr Allergy Immunol. 1997 Aug;8(3):112-20. doi: 10.1111/j.1399-3038.1997.tb00163.x.
Eosinophil cationic protein (ECP) has been reported to reflect the eosinophil inflammatory activity in asthma. However, the relative impact of asthma symptoms and atopic eczema upon serum (s)-ECP in asthmatic children has not been established.
To examine s-ECP levels and s-myeloperoxidase (MPO) in relation to asthma symptoms and atopic eczema in asthmatic children.
S-ECP and s-MPO were assessed in relation to symptom activity, lung function, exercise-induced bronchoconstriction and bronchial responsiveness in 101 children; median age 9 years, range 1-16 years; with moderate to severe asthma, admitted to Voksentoppen Center.
S-ECP was significantly higher in children with persistent compared to episodic or no asthma symptoms in the past four weeks. S-ECP was also higher in children with atopic compared to non-atopic asthma, as well as in those with active compared to past history or no history of atopic eczema. S-MPO was higher in children with persistent asthma symptoms, but did not differ in relation to atopy or eczema state. Persistent asthma symptoms had the greatest impact upon s-ECP levels, followed by atopy and active eczema.
S-ECP may be used in assessing symptom activity in asthmatic children, but with the realisation that active eczema and the presence of atopy may also influence levels.
据报道，嗜酸性粒细胞阳离子蛋白（ECP）可反映哮喘中的嗜酸性粒细胞炎症活动。然而，哮喘症状和特应性湿疹对哮喘儿童血清（s）-ECP的相对影响尚未明确。
研究哮喘儿童的s-ECP水平和s-髓过氧化物酶（MPO）与哮喘症状和特应性湿疹的关系。
对101名年龄中位数为9岁（范围1-16岁）、患有中度至重度哮喘并入住Voksentoppen中心的儿童，评估其s-ECP和s-MPO与症状活动、肺功能、运动诱发的支气管收缩和支气管反应性的关系。
在过去四周内有持续性哮喘症状的儿童，其s-ECP显著高于发作性或无哮喘症状的儿童。特应性哮喘儿童的s-ECP也高于非特应性哮喘儿童，有特应性湿疹活动史的儿童高于有特应性湿疹既往史或无特应性湿疹史的儿童。持续性哮喘症状儿童的s-MPO较高，但与特应性或湿疹状态无关。持续性哮喘症状对s-ECP水平影响最大，其次是特应性和活动性湿疹。
s-ECP可用于评估哮喘儿童的症状活动，但应认识到活动性湿疹和特应性的存在也可能影响其水平。
