Serum total, heat and urea stable alkaline phosphatase activities in relation to ABO blood groups and secretor phenotypes.

The relationship between serum alkaline phosphatase (AP) isoenzymes, ABO blood groups and secretor phenotypes was evaluated in 125 Nigerian voluntary blood donors. The serum total AP activity patterns were group O > Group B > Group AB > Group A, but only the differences between A/B, A/O and AB/O were significant. The total and activities of the different isoenzymes were lowest in group A, while highest values were found in group O. The different activities for group AB were intermediate between the levels for A and B. The activities of the different isoenzymes tended to be higher in secretors than in non-secretors. Our results may suggest that both the blood group and secretor genes are strong determinants of AP isoenzyme patterns in Nigeria.