Guseva I A, Moshnina M A, Krylov M Iu, Edres Sh, Alekseeva L I
Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow, Russia.
Genetika. 1998 Jan;34(1):100-5.
Distributions and gametic associations of HLA I antigens were studied in two Finno-Ugrian populations of Russia: Mordovians (300 subjects, including 148 Erzyas and 152 Mokshas) and Maris (137 subjects). Regarding the Mordovian population, Erzya and Moksh subpopulations significantly differed from each other only in the frequency of the A9 antigen. However, the Mari and Mordovian populations differed from each other considerably. Maris exhibited higher frequencies of antigens A9, B27, and B40 and lower frequencies of B5, B8, and B16 compared to Erzyas, as well as higher frequencies of A3, A28, B27, and B40 and lower frequencies of A10, B5, B8, B16, and B18 compared to Moksha. In addition, Erzyas, Mokshas, and Maris differed from one another in the gametic associations revealed. In general, our data indicated that the three populations, which display characteristic features of both Caucasoid and Mongoloid races, differ from one another with respect to the HLA genetic polymorphism. In all of the three populations, a positive association of the B27 antigen with spondylarthropathies (SAPs) was revealed. This confirms the hypothesis that B27 is involved in the pathogenesis of some rheumatoid diseases.
对俄罗斯两个芬兰-乌戈尔族群的HLA I类抗原分布及配子关联进行了研究：莫尔多瓦人（300名受试者，包括148名埃尔齐亚人和152名莫克沙人）和马里人（137名受试者）。关于莫尔多瓦人群体，埃尔齐亚和莫克沙亚群体仅在A9抗原频率上存在显著差异。然而，马里人和莫尔多瓦人群体彼此差异较大。与埃尔齐亚人相比，马里人A9、B27和B40抗原频率较高，B5、B8和B16抗原频率较低；与莫克沙人相比，马里人A3、A28、B27和B40抗原频率较高，A10、B5、B8、B16和B18抗原频率较低。此外，埃尔齐亚人、莫克沙人和马里人在所揭示的配子关联方面也彼此不同。总体而言，我们的数据表明，这三个兼具高加索人种和蒙古人种特征的群体在HLA基因多态性方面彼此不同。在所有这三个群体中，均发现B27抗原与脊柱关节病（SAPs）呈正相关。这证实了B27参与某些类风湿疾病发病机制的假说。
