Drummond G S, Kappas A
Rockefeller University Hospital, New York, N.Y. 10021, USA.
Pharmacology. 1998 Mar;56(3):158-64. doi: 10.1159/000028194.
Sn-mesoporphyrin (SnMP), a potent inhibitor of heme oxygenase (HO), controlled hyperbilirubinemia in rats of the mutant strain EHBR/Eis. This mutant strain displays pronounced conjugated hyperbilirubinuria and dark pigmentation of hepatocytes, characteristics of the Dubin-Johnson syndrome. SnMP administered at a dose of 10 mumol/kg body weight produced an immediate decrease in plasma bilirubin concentrations which could be maintained by weekly injections of this synthetic heme analogue. Marked inhibition of HO activity was demonstrated in liver, kidney and spleen but not in brain. These results demonstrate that SnMP can lower plasma bilirubin concentrations for extended periods in a new mutant rat model of Dubin-Johnson syndrome.
锡-中卟啉（SnMP）是血红素加氧酶（HO）的强效抑制剂，可控制突变株EHBR/Eis大鼠的高胆红素血症。该突变株表现出明显的结合性高胆红素尿症和肝细胞色素沉着，这是杜宾-约翰逊综合征的特征。以10 μmol/kg体重的剂量给予SnMP可使血浆胆红素浓度立即降低，通过每周注射这种合成血红素类似物可维持该效果。在肝脏、肾脏和脾脏中均显示出对HO活性的显著抑制，但在大脑中未观察到。这些结果表明，在杜宾-约翰逊综合征的新突变大鼠模型中，SnMP可长期降低血浆胆红素浓度。
