Bartels J, Maune S, Meyer J E, Kulke R, Schlüter C, Röwert J, Christophers E, Schröder J M
Department of Dermatology, University of Kiel, Germany.
Rhinology. 1997 Dec;35(4):171-4.
Eosinophilic tissue infiltration of nasal mucosa typical for allergic rhinitis and chronic polypous sinusitis may be due to chemotactic activity of chemokines specific for eosinophils. The CC-chemokines eotaxin, RANTES and MCP-3 have been postulated to be involved in the recruitment of eosinophils to certain inflamed tissues. To explore their possible role in chronic polypous sinusitis we examined eotaxin-, RANTES- and MCP-3-gene expression in human nasal polyps and normal human nasal mucosa of patients undergoing endonasal surgery for treatment of chronic polypous sinusitis. Using gene-specific primers in semi-quantitative reverse-transcriptase polymerase-chain-reaction experiments we found elevated expression of eotaxin- and RANTES-mRNA but no MCP-3-mRNA in non-atopic and atopic nasal polyps when compared to normal nasal mucosa.
过敏性鼻炎和慢性息肉性鼻窦炎典型的鼻黏膜嗜酸性粒细胞组织浸润可能归因于对嗜酸性粒细胞具有特异性的趋化因子的趋化活性。CC趋化因子嗜酸性粒细胞趋化蛋白、调节激活正常T细胞表达和分泌的因子及单核细胞趋化蛋白-3被推测参与嗜酸性粒细胞向某些炎症组织的募集。为探究它们在慢性息肉性鼻窦炎中的可能作用，我们检测了接受鼻内手术治疗慢性息肉性鼻窦炎患者的人鼻息肉和正常人鼻黏膜中嗜酸性粒细胞趋化蛋白、调节激活正常T细胞表达和分泌的因子及单核细胞趋化蛋白-3基因的表达。在半定量逆转录聚合酶链反应实验中使用基因特异性引物，我们发现与正常鼻黏膜相比，非特应性和特应性鼻息肉中嗜酸性粒细胞趋化蛋白和调节激活正常T细胞表达和分泌的因子的信使核糖核酸表达升高，但单核细胞趋化蛋白-3信使核糖核酸未升高。
