Department of Otolaryngology, Shuang-Ho Hospital, Taipei Medical University, 291 Jhongjheng Rd, Jhonghe, 235, New Taipei, Taiwan, ROC.
Eur Arch Otorhinolaryngol. 2012 Nov;269(11):2343-8. doi: 10.1007/s00405-012-1927-5. Epub 2012 Jan 24.
Eosinophilia occurs in up to 75-90% of nasal polyps in Caucasians. The chemokines eotaxin and RANTES increase eosinophil recruitment, activation, and survival, and these chemokines are significantly expressed in nasal polyps. We hypothesized that eotaxin and RANTES plasma levels might be correlated with disease severity. We compared the eotaxin and RANTES plasma levels in 20 Taiwanese patients with chronic rhinosinusitis and nasal polyps and 20 Taiwanese healthy controls. Eotaxin and RANTES plasma levels were measured by ELISA and disease severity was scored by CT scans. Compared to controls, patients with nasal polyps had significantly elevated plasma levels of eotaxin and RANTES and increased peripheral blood eosinophils (p < 0.001). Eotaxin plasma levels were significantly correlated with disease severity in patients with chronic rhinosinusitis to a greater extent than were RANTES levels. RANTES and eotaxin levels were also positively correlated with the percentages of peripheral blood eosinophils. Eotaxin plasma levels are significantly correlated with disease severity in Taiwanese patients with nasal polyposis to a greater degree than are RANTES levels. Additional studies are needed to assess whether eotaxin plasma levels can be used to monitor disease progression and attenuation.
嗜酸性粒细胞增多症发生于高达 75-90%的白种人鼻息肉中。趋化因子 eotaxin 和 RANTES 增加嗜酸性粒细胞的募集、激活和存活，这些趋化因子在鼻息肉中表达明显。我们假设 eotaxin 和 RANTES 血浆水平可能与疾病严重程度相关。我们比较了 20 例台湾地区慢性鼻-鼻窦炎伴鼻息肉患者和 20 例台湾地区健康对照者的 eotaxin 和 RANTES 血浆水平。通过 ELISA 测量 eotaxin 和 RANTES 血浆水平，并通过 CT 扫描评分疾病严重程度。与对照组相比，鼻息肉患者的 eotaxin 和 RANTES 血浆水平显著升高，外周血嗜酸性粒细胞增多（p<0.001）。eotaxin 血浆水平与慢性鼻-鼻窦炎患者的疾病严重程度呈显著正相关，其相关性大于 RANTES 水平。RANTES 和 eotaxin 水平也与外周血嗜酸性粒细胞百分比呈正相关。eotaxin 血浆水平与台湾地区鼻息肉患者的疾病严重程度的相关性大于 RANTES 水平。需要进一步研究以评估 eotaxin 血浆水平是否可用于监测疾病进展和减轻。
