Belova L A, Arkhapkova I A, Ogloblina O G, Eliseev A O, Chuĭkin N A, Kukharchuk V V, Arabidze G G
Ter Arkh. 1998;70(1):26-9.
Development of a protocol of multiple-modality treatment of patients with nonspecific aortoarteritis (NAA) making use of plasmapheresis and specific plasma adsorption of proteinases.
Six patients with NAA aged 15 to 58 years were examined using ultrasonic dopplerography, magnetic imaging, and angiography of the large vessels. Red cell sedimentation rate was assessed, cathepsin G activity, antitryptic activity, and content of C-reactive protein in the blood measured. Drug therapy was supplemented by repeated sessions of plasmapheresis and specific plasma adsorption on immotin.
After sessions of plasmapheresis (n = 17) and plasma adsorption (n = 13), increased cathepsin G activity dropped by at least 30% (in 3 patients it normalized), the content of C-reactive protein decreased in the presence of normal antitryptic activity (in patients with decreased activity it normalized and in those with increased values a tendency to normalization was observed). Red cell sedimentation rate decreased, particularly so 1 and 2 months after treatment; the patients felt better.
Multiple-modality treatment of NAA patients making use of plasmapheresis and plasma adsorption decreases the activity of the inflammatory process.
制定一种利用血浆置换和蛋白酶特异性血浆吸附对非特异性主动脉动脉炎（NAA）患者进行多模式治疗的方案。
对6例年龄在15至58岁之间的NAA患者进行了超声多普勒检查、磁共振成像和大血管血管造影。评估红细胞沉降率，测量血液中的组织蛋白酶G活性、抗胰蛋白酶活性和C反应蛋白含量。药物治疗辅以重复的血浆置换和在免疫球蛋白上的特异性血浆吸附。
在进行血浆置换（n = 17）和血浆吸附（n = 13）后，升高的组织蛋白酶G活性至少下降了30%（3例患者恢复正常），在抗胰蛋白酶活性正常的情况下C反应蛋白含量降低（活性降低的患者恢复正常，活性升高的患者有恢复正常的趋势）。红细胞沉降率下降，尤其是在治疗后1个月和2个月；患者感觉好转。
利用血浆置换和血浆吸附对NAA患者进行多模式治疗可降低炎症过程的活性。
