[鼠疫耶尔森氏菌“鼠”毒素的细胞因子诱导活性]

[The cytokine-inducing activity of the Yersinia pestis "murine" toxin].

作者信息

Vasil'eva G I, Mishan'kin M B, Kozlovskiĭ V N, Verkina L M, Mishan'kin B N

机构信息

Research Institute for Plague Control, Rostov-on-Don.

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1998 Jan-Feb(1):61-4.

PMID:9532689

Abstract

In this work the data obtained in the study of cytokinin-inducing activity of Y. pestis "mouse" toxin (MT) are presented. The study revealed that MT induced the synthesis of IL 1, IL 2 and TNF alpha. The most pronounced activity in MT was IL 2 inducing activity having dose-dependent character: the effect increased with the decrease of the dose of the preparation. The maximum level of the synthesis of IL 2 was observed when very low doses of the preparation (0.01 microgram/ml) were used, which was characteristic of superantigens. The presented data suggest that IL 2 plays an essential role in the mechanism of immunopathological reactions stipulated by MT.

摘要

本文展示了在对鼠疫耶尔森氏菌“小鼠”毒素（MT）的细胞分裂素诱导活性研究中获得的数据。研究发现，MT可诱导白细胞介素1（IL 1）、白细胞介素2（IL 2）和肿瘤坏死因子α（TNFα）的合成。MT中最显著的活性是具有剂量依赖性的IL 2诱导活性：随着制剂剂量的降低，效应增强。当使用极低剂量的制剂（0.01微克/毫升）时，观察到IL 2合成的最高水平，这是超抗原的特征。所呈现的数据表明，IL 2在MT规定的免疫病理反应机制中起重要作用。