Vershilova P A, Dranovskaia E A
Biull Eksp Biol Med. 1976 Mar;81(3):333-5.
The data on brucella nontoxic protective antigen without any sensitizing properties isolated from the cell wall of brucella are presented. The antigen had a marked protective effect against the experimental infection for 3-4 months after a single immunization of guinea pigs.Molecular heterogeneity of the antigen, which is mainly a protein-polysaccharide complex, is given. High- and low-molecular fractions detected by gel filtration technique differed according to the chemical and immunobiological characteristics. The high-molecular fraction of the antigen was found to be highly immunogenic and serologically active.
本文介绍了从布鲁氏菌细胞壁分离出的无致敏性的布鲁氏菌无毒保护性抗原的数据。该抗原在对豚鼠进行单次免疫后3至4个月内，对实验性感染具有显著的保护作用。文中给出了该主要为蛋白质 - 多糖复合物的抗原的分子异质性。通过凝胶过滤技术检测到的高分子和低分子组分在化学和免疫生物学特性上有所不同。发现该抗原的高分子组分具有高度免疫原性和血清学活性。
