Bolpe J, de Lapenta D F, García-Carrillo C
Departamento de Zoonosis Rurales, Provincia de Buenos Aires, Argentina.
Rev Inst Med Trop Sao Paulo. 1991 Jan-Feb;33(1):23-7.
A phenol insoluble extract vaccine proposed to immunize men against brucellosis was tested for its ability in protecting guinea pigs against challenge with virulent Brucella abortus strain 2308. Living attenuated Brucella abortus strain 19 and B. melitensis Rev. 1 were included in the experiment for comparison. Ninety three animals were vaccinated in each group and subdivided in subgroups of 31 for challenge with 10(4), 10(3) and 10(2) colony forming units of virulent B. abortus 2308. A global analysis of the results showed protection of 11.9%, 65% and 95% in animals vaccinated with phenol insoluble extract, strain 19 and Rev. 1, respectively.
一种提议用于男性预防布鲁氏菌病的酚不溶性提取物疫苗，针对其保护豚鼠抵御强毒流产布鲁氏菌2308菌株攻击的能力进行了测试。实验中纳入了减毒活疫苗流产布鲁氏菌19株和马尔他布鲁氏菌Rev.1株作为对照。每组93只动物接种疫苗，并再分为31只动物的亚组，分别用10⁴、10³和10²个强毒流产布鲁氏菌2308菌株的菌落形成单位进行攻击。结果的整体分析显示，接种酚不溶性提取物、19株和Rev.1株疫苗的动物保护率分别为11.9%、65%和95%。
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