Gabrielian E S, Amroian E A
Biull Eksp Biol Med. 1976 Jun;81(6):643-5.
Acute experiments were conducted on cats; vasoconstrictor action of noradrenaline on the cerebral vessels and arterial pressure were considerably depressed under conditions of hypocapnia. Inhibition of prostaglandin biosynthesis with indomethacin against the background of continuing hypocapnia promoted marked elevation of cerebrovascular resistance and of arterial pressure in response to intracarotid noradrenaline injection. A hypothetical scheme of prostaglandin participation in the regulation of the tone of the cerebral vessels in hypocapnia and adrenergic actions is presented.
在猫身上进行了急性实验；在低碳酸血症条件下，去甲肾上腺素对脑血管的血管收缩作用和动脉血压显著降低。在持续低碳酸血症背景下，用吲哚美辛抑制前列腺素生物合成，可促进在颈动脉注射去甲肾上腺素后脑血管阻力和动脉血压显著升高。本文提出了前列腺素参与低碳酸血症时脑血管张力调节和肾上腺素能作用的假说方案。
