Mace S R, Sussman G L, Liss G, Stark D F, Beezhold D, Thompson R, Kelly K
Department of Medicine, University of Toronto, Ontario, Canada.
Ann Allergy Asthma Immunol. 1998 Mar;80(3):252-6. doi: 10.1016/S1081-1206(10)62966-3.
To determine the prevalence of allergy to natural rubber latex and potential crossreacting foods in operating room nurses.
Two hundred forty-seven operating room nurses completed a latex allergy questionnaire. They were questioned about symptoms of latex reactivity and about other allergies particularly to foods that may crossreact with latex. Informed consent was obtained and skin prick testing was performed with natural rubber latex and five latex extracts representing low (0.08 to 0.25 microgram/mL) and high (18 to 106 micrograms/mL) natural rubber latex protein gloves. Skin prick tests were done with four potentially crossreacting foods (banana, avocado, kiwi, and potato), saline, and histamine controls.
One hundred thirty-five (54.7%) nurses described allergic symptoms they attributed to latex exposure. Of these 12 (4.9%) tested positive to latex extracts alone, 12 (4.9%) tested positive to food extracts alone, and 5 (2.0%) tested positive to both latex and crossreactive foods. Three of the 17 (17.6%) nurses testing positive to latex gave no history of reactivity to latex. Indirect latex ELISA was done on the serum of skin test-positive patients with a 70.6% sensitivity.
Of the nurses tested, 6.9% had positive skin prick tests to latex extracts; 17.6% of these were asymptomatic and 29.4% had associated food positive skin prick tests.
确定手术室护士对天然橡胶乳胶过敏以及潜在交叉反应性食物的患病率。
247名手术室护士完成了一份乳胶过敏问卷。询问她们乳胶反应性症状以及其他过敏情况，尤其是对可能与乳胶发生交叉反应的食物的过敏情况。获得知情同意后，用天然橡胶乳胶以及五种代表低（0.08至0.25微克/毫升）和高（18至106微克/毫升）天然橡胶乳胶蛋白手套的乳胶提取物进行皮肤点刺试验。用四种潜在交叉反应性食物（香蕉、鳄梨、猕猴桃和土豆）、生理盐水和组胺对照进行皮肤点刺试验。
135名（54.7%）护士描述了她们认为归因于乳胶暴露的过敏症状。其中，12名（4.9%）仅对乳胶提取物检测呈阳性，12名（4.9%）仅对食物提取物检测呈阳性，5名（2.0%）对乳胶和交叉反应性食物均检测呈阳性。在17名对乳胶检测呈阳性的护士中，有3名（17.6%）没有乳胶反应史。对皮肤试验阳性患者的血清进行间接乳胶ELISA检测，敏感性为70.6%。
在所检测的护士中，6.9%对乳胶提取物皮肤点刺试验呈阳性；其中17.6%无症状，29.4%伴有食物皮肤点刺试验阳性。
