[Concentration of adenylic nucleotides and respiratory phosphorylation in the mitochondria of rats with transplanted tumors].
作者信息
Morozkina T S, Shapot V S
出版信息
Biull Eksp Biol Med. 1976 Jun;81(6):727-9.
PMID:953312
Abstract
A study was made of adenylic mononucleotides, the process of oxydative phosphorylation and ATP-ase activity of hepatic mitochondria of rats with transplantable sarcoma 45 and Walker carcinosarcoma at various stages of tumour growtli. A reduction of the ATP levels observed in the hepatic mitochondria of tumour-bearing rats was caused, on the one hand, by suppression of its formation as a result of a partial uncoupling of the oxidative phosphorylation, and on the other hand - by intensification of its decomposition as a result of increased ATP-ase activity.
摘要
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