Moulé Y
Toxicol Eur Res. 1978;1(5):283-8.
Zineb (zinc ethylene bisdithiocarbamate) inhibits the transcriptional activity of an in vitro system functioning with either RNA polymerases of isolated rat liver nuclei or purified E. coli RNA polymerase. Zineb also inhibits the in vitro aminoacid incorporation mediated by a polysomal standard system, by interacting with some pH 5 enzyme components(s). When rats fed a balanced semi-synthetic diet containing zineb (5 200 mg/kg) for ten weeks, one may observe a decrease in the RNA and protein syntheses in liver. The consequences of the ingestion of small but repeated doses of zineb are discussed.
代森锌（乙撑双二硫代氨基甲酸锌）可抑制一个体外系统的转录活性，该系统可与分离的大鼠肝细胞核的RNA聚合酶或纯化的大肠杆菌RNA聚合酶一起发挥作用。代森锌还可通过与某些pH 5酶成分相互作用，抑制多核糖体标准系统介导的体外氨基酸掺入。当给大鼠喂食含代森锌（5200毫克/千克）的平衡半合成饮食十周时，可观察到肝脏中RNA和蛋白质合成减少。文中讨论了摄入少量但反复剂量代森锌的后果。
