Bonfiglio G, Carciotto V, Russo G, Stefani S, Schito G C, Debbia E, Nicoletti G
Istituto di Microbiologia, Università di Catania, Italy.
J Antimicrob Chemother. 1998 Feb;41(2):307-10. doi: 10.1093/jac/41.2.307.
In order to assess the current level of resistance to widely used antipseudomonal antibiotics in clinical isolates of Pseudomonas aeruginosa, a national survey was undertaken. Fifteen hospitals throughout Italy participated in the study. The University of Catania tested the antibiotic susceptibility of 1005 consecutive clinically significant P. aeruginosa collected from March to June 1995. Lack of susceptibility, according to NCCLS breakpoints, was at the following rates: meropenem, 9.1%; imipenem, 19.3%; ceftazidime, 13.4%; carbenicillin, 27.3%; piperacillin, 12%; ticarcillin/clavulanic acid, 22.8%; amikacin, 10.6%; and ciprofloxacin, 31.9%. About half of the isolates (44.4%) were not susceptible to at least one of the antibiotics tested.
为评估铜绿假单胞菌临床分离株对广泛使用的抗假单胞菌抗生素的当前耐药水平，开展了一项全国性调查。意大利各地的15家医院参与了该研究。卡塔尼亚大学检测了1995年3月至6月连续收集的1005株具有临床意义的铜绿假单胞菌的抗生素敏感性。根据美国国家临床实验室标准委员会（NCCLS）的断点标准，耐药率如下：美罗培南9.1%；亚胺培南19.3%；头孢他啶13.4%；羧苄西林27.3%；哌拉西林12%；替卡西林/克拉维酸22.8%；阿米卡星10.6%；环丙沙星31.9%。约一半的分离株（44.4%）对至少一种测试抗生素耐药。
