Mutirangura A, Pornthanakasem W, Theamboonlers A, Sriuranpong V, Lertsanguansinchi P, Yenrudi S, Voravud N, Supiyaphun P, Poovorawan Y
Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Clin Cancer Res. 1998 Mar;4(3):665-9.
This study evaluated Epstein-Barr virus (EBV) DNA in sera of 42 patients with nasopharyngeal carcinoma (NPC) and 82 healthy individuals who had been infected previously with EBV. Thirteen of 42 NPC samples were positive for EBV DNA in their sera, whereas all 82 normal controls were negative. In addition, EBV typing between primary tumors and sera showed identical results, suggesting that serum EBV DNA represented tumor DNA. To evaluate the importance of the serum NPC DNA, clinical data and tumor phenotypes including age, sex, WHO type, EBV type, stage, tumor invasion, metastasis, and apoptosis were correlated with serum EBV DNA, and only apoptosis was found statistically significant. In conclusion, EBV DNA was detectable in the serum of some patients with NPC, represented tumor DNA, and might have clinical implications in the future.
本研究评估了42例鼻咽癌（NPC）患者和82例既往感染过爱泼斯坦-巴尔病毒（EBV）的健康个体血清中的EBV DNA。42份NPC样本中有13份血清EBV DNA呈阳性，而所有82名正常对照均为阴性。此外，原发肿瘤与血清之间的EBV分型显示结果相同，表明血清EBV DNA代表肿瘤DNA。为评估血清NPC DNA的重要性，将临床数据和肿瘤表型（包括年龄、性别、WHO分型、EBV分型、分期、肿瘤侵袭、转移和凋亡）与血清EBV DNA进行关联分析，结果发现只有凋亡具有统计学意义。总之，部分NPC患者血清中可检测到EBV DNA，其代表肿瘤DNA，未来可能具有临床意义。
