Melana S M, Holland J F, Pogo B G
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.
Clin Cancer Res. 1998 Mar;4(3):693-6.
The effect of zidovudine (3'-azido-3'-deoxythymidine; AZT) was investigated in four breast cancer cell lines, a T4 cell leukemia, and a normal breast cell line in vitro. AZT inhibited the growth of all tumoral cell lines, but it did so in a wide range of concentrations. The growth of a normal breast cell line was also inhibited, although it required a much higher concentration. Furthermore, AZT inhibited colony formation in soft agar and telomerase activity. These results indicated that AZT can be potentially used, alone or in combination, as an anti-breast cancer agent.
在体外对四种乳腺癌细胞系、一种T4细胞白血病细胞系和一种正常乳腺细胞系研究了齐多夫定（3'-叠氮-3'-脱氧胸苷；AZT）的作用。AZT抑制了所有肿瘤细胞系的生长，但所需浓度范围很广。正常乳腺细胞系的生长也受到抑制，不过所需浓度要高得多。此外，AZT抑制软琼脂中的集落形成和端粒酶活性。这些结果表明，AZT有可能单独或联合用作抗乳腺癌药物。
