Kovalenko T M
Biull Eksp Biol Med. 1976 Jul;82(7):868-71.
Prolonged administration of cortisone to sexually immature rabbits and rats, in which m. tibialis anterior was injured preliminarily, inhibited the process of regeneration of the skeletal muscle tissue; this was expressed in the retarded growth of myosymplasts and of the muscle tubes. By the 15th postoperative day experimental rabbits (in comparison with control) showed a lesser area of muscle component of the regenerated tissue. Analysis of the intensity of methionine-H3 incorporation into the regenerating elements of the muscle tissue demonstrated a significant reduction of the label incorporation into the nuclear and cytoplasmic proteins of the myosymplasts of rats to which cortisone was given. Inhibition of the protein synthesis at the early stage of differentiation of the muscle tissue was expressed to a lesser extent than in the mature differentiated muscle fibers of the intact muscle.
对性未成熟的兔和大鼠预先损伤其胫前肌后长期给予可的松，会抑制骨骼肌组织的再生过程；这表现为肌合胞体和肌管生长迟缓。术后第15天，实验兔（与对照组相比）再生组织的肌肉成分面积较小。对肌肉组织再生成分中蛋氨酸-H3掺入强度的分析表明，给予可的松的大鼠肌合胞体的核蛋白和胞质蛋白中，标记物的掺入显著减少。肌肉组织分化早期蛋白质合成的抑制程度，低于完整肌肉中成熟分化的肌纤维。
