Ostrovskiĭ A A, Nikitin V S
Vopr Pitan. 1985 Jul-Aug(4):48-51.
Light microscopy was employed to study the development of posttraumatic aseptic inflammation and subsequent regeneration in the affected musculus soleus in different patterns of hypovitaminosis B1. Alimentary deficiency of thiamine entailed pronounced retardation of the post-traumatic inflammation. The growth of macrophage density and formation of the pool of the regenerating cells were also retarded. On day 21 the regeneration pool showed an elevated content of the connective tissue. During long-term administration of oxythiamine in a dose of 10 mg/kg with a 12-hour interval, the development of the inflammatory response was marked by similar alterations, but the formation of muscle fibers and connective tissue proceeded more uniformly. A single administration of oxythiamine in a dose of 200 mg/kg did not bring about any substantial impairment of the early stages of regeneration. The alterations observed can be associated with different degree of inhibition of the activity of TDF-containing enzymes and derangement of the function of the nervous system.
采用光学显微镜研究不同模式的维生素B1缺乏症对受影响的比目鱼肌创伤后无菌性炎症发展及随后再生的影响。硫胺素的饮食缺乏导致创伤后炎症明显延迟。巨噬细胞密度的增加和再生细胞池的形成也受到抑制。在第21天，再生池中结缔组织含量升高。以10mg/kg的剂量、12小时间隔长期给予羟硫胺素时，炎症反应的发展表现出类似的改变，但肌纤维和结缔组织的形成更为均匀。单次给予200mg/kg的羟硫胺素并未对再生早期造成任何实质性损害。观察到的改变可能与含硫胺素焦磷酸酶的酶活性受到不同程度的抑制以及神经系统功能紊乱有关。
