年轻女性心肌梗死的危险因素。
Risk factors for myocardial infarction in young women.
作者信息
Mann J I, Doll R, Thorogood M, Vessey M P, Waters W E
出版信息
Br J Prev Soc Med. 1976 Jun;30(2):94-100. doi: 10.1136/jech.30.2.94.
Abstract
Seventy-seven women discharged from hospital with a diagnosis of myocardial infarction and 207 control patients were investigated. All were under 45 years of age at the time of admission. Heavy cigarette smoking, reported treatment for pre-eclamptic toxaemia, and type II hyperlipoproteinaemia were found to be independent risk factors for myocardial infarction. Reported treatment for hypertension and diabetes are probably also independently associated with subsequent development of the condition, but the associations between myocardial infarction and reported treatment for obesity and psychiatric illness appear to be secondary. Previous publications have suggested that use of oral contraceptives is an independent risk factor. Examination of the effect of several factors combined, suggests that they act synergistically, the presence of three or more factors increasing the risk 128-fold.
摘要
对77名诊断为心肌梗死出院的女性和207名对照患者进行了调查。所有患者入院时年龄均在45岁以下。发现重度吸烟、先兆子痫前期的报告治疗史和II型高脂蛋白血症是心肌梗死的独立危险因素。高血压和糖尿病的报告治疗史可能也与该病的后续发展独立相关，但心肌梗死与肥胖和精神疾病报告治疗史之间的关联似乎是次要的。以前的出版物表明，使用口服避孕药是一个独立危险因素。对几种因素综合作用的研究表明，它们具有协同作用，三种或更多因素的存在会使风险增加128倍。
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