Hendry J H, Rosenberg I, Greene D, Stewart J G
Br J Radiol. 1976 Aug;49(584):690-9. doi: 10.1259/0007-1285-49-584-690.
The rat tail has been used as a model system to study the necrosis of an organized tissue following fractionated doses of collimated D-T neutrons or 290 kV X rays. RBE values for tail tolerance - 10 per cent of tails necrosing after the early skin reactions - rise from about 1-7 (single doses) to about 3-1 (16 fractions in 22 days). Neutron tolerance doses are almost independent of fractionation from 2 to 16 fractions. The tissues at risk are shown to be rather hypoxic. Early skin reaction levels can be used to predict the fraction of tails that will necrose. Early peak reactions for a given fraction of necrotic tails were slightly higher for neutrons than for X rays, and this difference was consistent for all the dose fractionation schedules employed.
大鼠尾巴已被用作模型系统，以研究分次剂量的准直D-T中子或290 kV X射线照射后有组织的组织坏死情况。尾巴耐受性的相对生物效应（RBE）值——早期皮肤反应后10%的尾巴发生坏死——从约1.7（单次剂量）升至约3.1（22天内分16次照射）。中子耐受剂量在2至16次分割照射时几乎与分割无关。研究表明，受影响的组织相当缺氧。早期皮肤反应水平可用于预测将会发生坏死的尾巴比例。对于给定比例的坏死尾巴，中子照射后的早期峰值反应略高于X射线照射后的反应，并且这种差异在所采用的所有剂量分割方案中都是一致的。
