Andreozzi U, Hornsey S, Myers R
Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Jul;36(1):33-41. doi: 10.1080/09553007914550791.
The skin reactions in aerated and hypoxic mouse tails after single or fractionated doses of 250 kV X-rays or fast neutrons (6 MeV deuterons on beryllium) have been measured. The o.e.r. for one to sixteen fractions of X-rays remains constant, while that for one to ten fractions of neutrons decreases with increasing neutron fractionation and decreasing neutron dose/fraction. The o.e.r. for X-rays was 1.7, for single-neutron doses 1.4, and for ten fractions of neutrons 1.25. It was anticipated that the o.e.r. for neutron-induced damage would decrease further as neutron fractionation is increased because the contribution to damage from the highest LET components of dose, the alpha and heavy recoil particles, would increase relative to the lowe LET components. The r.b.e. values obtained for skin damage were higher at all neutron doses/fraction examined in this study on tails than all those previously obtained in studies on skin at other sites on four species. This may be due to the influence of hypoxia on the r.b.e. measurements in the mouse tail.
已测量了单次或分次给予250 kV X射线或快中子（铍上的6 MeV氘核）后，通气和缺氧小鼠尾巴的皮肤反应。X射线一至十六次分次照射的氧增强比保持恒定，而中子一至十次分次照射的氧增强比则随着中子分次增加和中子剂量/分次减少而降低。X射线的氧增强比为1.7，单次中子剂量的氧增强比为1.4，十次中子分次照射的氧增强比为1.25。预计随着中子分次增加，中子诱导损伤的氧增强比会进一步降低，因为剂量中高传能线密度成分（α粒子和重反冲粒子）对损伤的贡献相对于低传能线密度成分会增加。在本研究中对尾巴进行的所有中子剂量/分次检查中，获得的皮肤损伤相对生物效应值均高于之前在四种物种其他部位皮肤研究中获得的所有值。这可能是由于缺氧对小鼠尾巴相对生物效应测量的影响。
