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用于确定与蛋白质结合的配体质子共振归属的异核X滤波器1H PFG双量子实验。

Heteronuclear X-filter 1H PFG double-quantum experiments for the proton resonance assignment of a ligand bound to a protein.

作者信息

Dalvit C, Ramage P, Hommel U

机构信息

NOVARTIS Pharma AG, Basel, CH-4002, Switzerland.

出版信息

J Magn Reson. 1998 Mar;131(1):148-53. doi: 10.1006/jmre.1997.1342.

DOI:10.1006/jmre.1997.1342
PMID:9533918
Abstract

A novel X-filter experiment based on 1H PFG DQ spectroscopy is described. Excellent suppression of proton bound to 13C and 15N is achieved. Successful application of the method to a protein-ligand complex is demonstrated.

摘要

描述了一种基于1H PFG DQ光谱学的新型X-滤光器实验。实现了对与13C和15N结合的质子的出色抑制。证明了该方法在蛋白质-配体复合物中的成功应用。

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