UDR Napoli 4 (Consorzio INCA), IC-REACH Dipartimento di Chimica Organica e Biochimica, Università Federico II, Complesso Universitario Monte S. Angelo, Via Cinthia 4, I-80126 Napoli, Italy.
J Pharm Biomed Anal. 2011 Dec 5;56(4):678-83. doi: 10.1016/j.jpba.2011.07.005. Epub 2011 Jul 12.
Photochemical behaviour of indomethacin in aqueous media at 254nm, 310nm and sunlight was studied by HPLC. The drug exhibited a similar behaviour in all the irradiation experiments affording eight photoproducts that were separated and identified. The main photochemical routes are suggested to proceed via decarboxylation, followed by oxygenation to give an alcohol and an aldehyde and/or by solvent trapping to produce the alcohol. Photoinduced hydrolysis of CO-N bond and oxidative C2-C3 bond breakage also occur.
采用 HPLC 研究了吲哚美辛在 254nm、310nm 光照及日光下的光化学反应行为。该药物在所有辐照实验中表现出相似的行为，生成了 8 种光产物，这些产物被分离并鉴定。推测主要的光化学反应途径是通过脱羧，然后进行氧化生成醇和醛，或者通过溶剂捕获生成醇。还发生了 CO-N 键的光诱导水解和 C2-C3 键的氧化断裂。
