McGinn F P, Hamilton J C
Br J Surg. 1976 Jul;63(7):505-7. doi: 10.1002/bjs.1800630702.
Blood was obtained from 11 healthy voluteers, mixed with two standard types of anticoagulant used in blood transfusion centres and stored for 21-28 days at 4 degrees C. Leucocyte ascorbic acid (LAA) fell to deficient levels after 7 days in all cases. There were no corresponding changes in plasma ascorbic acid (PAA) levels. LAA and PAA were measured before, during and after surgery in 5 control patients who underwent definitive operations for benign peptic ulceration and in 4 patients under-going surgery for bleeding peptic ulceration. The average amount of blood administered to the latter group was 10 units. There was a fall in LAA and PAA in both groups of patients after operation. This fall had returned to normal by 7 days in the controls, but the LAA remained at a deficient level at 7 days in the patients who had bled. Deficient ascorbic acid in stored blood may contribute to low leucocyte ascorbic acid levels in patients after blood transfusion and may contribute to the increased complication rate when surgery is undertaken in these patients.
从11名健康志愿者身上采集血液，与输血中心使用的两种标准抗凝剂混合，并在4摄氏度下储存21至28天。在所有情况下，白细胞中的维生素C（LAA）在7天后降至缺乏水平。血浆维生素C（PAA）水平没有相应变化。对5例接受良性消化性溃疡根治手术的对照患者和4例因消化性溃疡出血接受手术的患者在手术前、手术期间和手术后测量了LAA和PAA。后一组患者平均输血量为10单位。两组患者术后LAA和PAA均下降。对照组中这种下降在7天时恢复正常，但出血患者在7天时LAA仍处于缺乏水平。储存血液中维生素C缺乏可能导致输血后患者白细胞维生素C水平降低，并可能导致这些患者进行手术时并发症发生率增加。
