从人类免疫缺陷病毒（HIV）脑部感染到痴呆症
From human immunodeficiency virus (HIV) infection of the brain to dementia.
作者信息
Trillo-Pazos G, Everall I P
机构信息
Department of Neuropathology, Institute of Psychiatry, London.
出版信息
Genitourin Med. 1997 Oct;73(5):343-7. doi: 10.1136/sti.73.5.343.
Abstract
Human immunodeficiency virus (HIV) can cause both primary and secondary brain diseases. Numerous neuropathological studies have shown that up to 90% of patients with acquired immune deficiency syndrome (AIDS) have lesions in the nervous system. In this review, we discuss the entry of HIV into the brain, the general features of HIV associated neuropathology, the role of different brain cells in HIV mediated neuronal damage, and the putative molecular mechanisms involved. We conclude by correlating which factors might be important in the development of HIV associated dementia.
摘要
人类免疫缺陷病毒（HIV）可引发原发性和继发性脑部疾病。众多神经病理学研究表明，高达90%的获得性免疫缺陷综合征（AIDS）患者存在神经系统病变。在本综述中，我们讨论了HIV进入大脑的过程、HIV相关神经病理学的一般特征、不同脑细胞在HIV介导的神经元损伤中的作用以及涉及的假定分子机制。我们通过关联哪些因素可能在HIV相关痴呆的发展中起重要作用来得出结论。
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