Kostner K, Hornykewycz S, Yang P, Neunteufl T, Glogar D, Weidinger F, Maurer G, Huber K
Department of Cardiology, University of Vienna, Austria.
Cardiovasc Res. 1997 Dec;36(3):330-6. doi: 10.1016/s0008-6363(97)00185-5.
Unstable angina pectoris often leads to acute myocardial infarction. Since lipid peroxidation is thought to be causally related to chronic and acute events in atherosclerosis and coronary artery disease, we measured lipid peroxidation products and vitamin E in 100 patients with coronary artery disease and compared them to a matched control group.
50 consecutive patients with stable angina pectoris (SAP) and 50 consecutive patients with unstable angina pectoris (UAP) were studied and compared to 100 clinically healthy individuals. In addition to conventional lipid and lipoprotein analysis, malondialdehydes were measured as thiobarbituric acid reactive substances (TBARS). Lipid hydroperoxides were assayed with the colorimetric methylene blue method. alpha-Tocopherol was quantitated by HPLC after extraction of serum with hexane-ethanol. In the patient group conjugated dienes were also measured.
As expected, patients had significantly higher cholesterol, triglyceride LDL-C and Lp(a) values and lower HDL-C values than controls. When patients were divided into groups with SAP and UAP respectively, peroxides and TBARS were significantly higher in the latter group as compared to patients with SAP and to controls. Conjugated dienes were also significantly higher in patients with UAP as compared to patients with SAP. Total plasma alpha-tocopherol was comparable in all three groups, whereas the alpha-tocopherol content per LDL particle was lowest in patients with UAP, followed by patients with SAP and then controls.
It is concluded that lipid peroxidation parameters are increased in patients with UAP and discriminate SAP from UAP patients.
不稳定型心绞痛常导致急性心肌梗死。由于脂质过氧化被认为与动脉粥样硬化和冠状动脉疾病的慢性及急性事件存在因果关系，我们对100例冠心病患者的脂质过氧化产物和维生素E进行了测定，并将其与匹配的对照组进行比较。
对50例连续的稳定型心绞痛（SAP）患者和50例连续的不稳定型心绞痛（UAP）患者进行研究，并与100名临床健康个体进行比较。除了常规的脂质和脂蛋白分析外，丙二醛作为硫代巴比妥酸反应物质（TBARS）进行测定。脂质氢过氧化物用比色法亚甲蓝法测定。用己烷 - 乙醇提取血清后，通过高效液相色谱法对α - 生育酚进行定量。在患者组中还测定了共轭二烯。
正如预期的那样，患者的胆固醇、甘油三酯、低密度脂蛋白胆固醇和脂蛋白（a）值显著高于对照组，而高密度脂蛋白胆固醇值低于对照组。当患者分别分为SAP组和UAP组时，与SAP患者和对照组相比，UAP组的过氧化物和TBARS显著更高。与SAP患者相比，UAP患者的共轭二烯也显著更高。三组的总血浆α - 生育酚相当，而每个低密度脂蛋白颗粒的α - 生育酚含量在UAP患者中最低，其次是SAP患者，然后是对照组。
得出结论，UAP患者的脂质过氧化参数升高，可将SAP患者与UAP患者区分开来。
