P2Y受体亚型在造血细胞上的分布。
Distribution of P2Y receptor subtypes on haematopoietic cells.
作者信息
Jin J, Dasari V R, Sistare F D, Kunapuli S P
机构信息
Department of Physiology, Temple University Medical School, Philadelphia, PA 19140, USA.
出版信息
Br J Pharmacol. 1998 Mar;123(5):789-94. doi: 10.1038/sj.bjp.0701665.
Abstract
- RT-PCR-southern hybridization analyses with radiolabelled P2Y receptor cDNAs as probes indicated that the peripheral blood leukocytes and the human umbilical vein endothelial cells express P2Y1, P2Y2, P2Y4 and P2Y6 receptors. 2. Of the haematopoietic cell lines tested, promonocytic U937 cells express P2Y2 and P2Y6, but not P2Y1 or P2Y4; promyelocytic HL-60 cells express the P2Y1, P2Y2 and P2Y6 receptors but not the P2Y4 receptor; K562 cells express P2Y1 but not P2Y2, P2Y4 or P2Y6; and Dami cells express P2Y1, P2Y2, P2Y4 and P2Y6 receptors. 3. Of the peripheral blood leukocytes tested, polymorphonuclear cells express P2Y4 and P2Y6 but not P2Y1 or P2Y2 receptors; monocytes express P2Y1, P2Y2, P2Y4 and P2Y6 receptors and lymphocytes express P2Y1, P2Y2, P2Y4 and P2Y6 receptors. 4. These results suggest a physiological role for different P2Y receptor subtypes in the extracellular nucleotide-mediated stimulation of monocytes, neutrophils, lymphocytes and endothelial cells.
摘要
- 以放射性标记的P2Y受体cDNA为探针进行的RT-PCR- Southern杂交分析表明，外周血白细胞和人脐静脉内皮细胞表达P2Y1、P2Y2、P2Y4和P2Y6受体。2. 在测试的造血细胞系中，单核细胞样U937细胞表达P2Y2和P2Y6，但不表达P2Y1或P2Y4；早幼粒细胞样HL-60细胞表达P2Y1、P2Y2和P2Y6受体，但不表达P2Y4受体；K562细胞表达P2Y1，但不表达P2Y2、P2Y4或P2Y6；而Dami细胞表达P2Y1、P2Y2、P2Y4和P2Y6受体。3. 在测试的外周血白细胞中，多形核细胞表达P2Y4和P2Y6，但不表达P2Y1或P2Y2受体；单核细胞表达P2Y1、P2Y2、P2Y4和P2Y6受体，淋巴细胞表达P2Y1、P2Y2、P2Y4和P2Y6受体。4. 这些结果表明不同的P2Y受体亚型在细胞外核苷酸介导的单核细胞、中性粒细胞、淋巴细胞和内皮细胞刺激中具有生理作用。
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