Van Parijs L, Abbas A K
Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Science. 1998 Apr 10;280(5361):243-8. doi: 10.1126/science.280.5361.243.
The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.
免疫系统以一种受调控的方式对微生物作出反应并将其清除，但不会对自身抗原产生反应。有几种调节机制发挥作用来终止对外来抗原的反应，在抗原被清除后使免疫系统恢复到基础状态，并维持对自身抗原的无反应性或耐受性。在此，我们将审视在免疫稳态机制的分子基础和生理作用理解方面的最新进展。
