Wu Henry Yim, Weiner Howard L
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Immunol Res. 2003;28(3):265-84. doi: 10.1385/IR:28:3:265.
Autoimmune conditions caused by injurious immune responses against self-antigens can be ameliorated if the inappropriate responses to self-components that cause tissue injury can be modulated by regulatory cells or shut off via the induction of anergy or via deletion of pathogenic immune responses. Antigen encounter at the gut mucosa can lead to suppression of injurious immune responses to self-antigen via these mechanisms. This type of immunological event is termed oral tolerance. In this review, we examine the mechanisms behind the induction of oral tolerance and provide findings from its use as a form of treatment for autoimmune diseases.
如果针对自身抗原的有害免疫反应所引发的自身免疫性疾病，能够通过调节性细胞来调节对自身成分的不适当反应，或者通过诱导无反应性或消除致病性免疫反应来阻断，那么这些疾病就可以得到改善。在肠道黏膜处遇到抗原可通过这些机制抑制对自身抗原的有害免疫反应。这种免疫事件被称为口服耐受。在本综述中，我们研究了诱导口服耐受背后的机制，并提供了将其用作自身免疫性疾病治疗形式的研究结果。
