病毒的免疫逃逸策略。

Viral strategies of immune evasion.

作者信息

Ploegh H L

机构信息

Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Science. 1998 Apr 10;280(5361):248-53. doi: 10.1126/science.280.5361.248.

DOI:10.1126/science.280.5361.248

PMID:9535648

Abstract

The vertebrate body is an ideal breeding ground for viruses and provides the conditions that promote their growth, survival, and transmission. The immune system evolved and deals with this challenge. Mutually assured destruction is not a viable evolutionary strategy; thus, the study of host-virus interactions provides not only a glimpse of life at immunity's edge, but it has also illuminated essential functions of the immune system, in particular, the area of major histocompatibility complex-restricted antigen presentation.

摘要

脊椎动物的身体是病毒的理想滋生地，为病毒的生长、存活及传播提供了条件。免疫系统不断进化以应对这一挑战。相互确保摧毁并非可行的进化策略；因此，对宿主-病毒相互作用的研究不仅让我们得以一窥免疫系统边缘的生命现象，还阐明了免疫系统的重要功能，尤其是主要组织相容性复合体限制的抗原呈递领域。