全细胞百日咳疫苗和无细胞百日咳疫苗在儿童中诱导产生的不同T细胞亚群。
Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children.
作者信息
Ryan M, Murphy G, Ryan E, Nilsson L, Shackley F, Gothefors L, Oymar K, Miller E, Storsaeter J, Mills K H
机构信息
Department of Biology, National University of Ireland, Maynooth, Ireland.
出版信息
Immunology. 1998 Jan;93(1):1-10. doi: 10.1046/j.1365-2567.1998.00401.x.
Abstract
Recent clinical trials have demonstrated that new generation acellular pertussis vaccines can confer protection against whooping cough. However, the mechanism of protective immunity against Bordetella pertussis infection induced by vaccination remains to be defined. We have examined cellular immune responses in children immunized with a range of acellular and whole cell pertussis vaccines. Immunization of children with a potent whole-cell vaccine induced B. pertussis-specific T cells that secreted interferon-gamma (IFN-gamma), but not interleukin-5 (IL-5). In contrast, T cells from children immunized with acellular pertussis vaccines secreted IFN-gamma and/or IL-5 following stimulation with B. pertussis antigens in vitro. These observations suggest that protective immunity conferred by whole-cell vaccines, like natural immunity, is mediated by type 1 T cells, whereas the mechanism of immune protection generated with acellular vaccines may be more heterogeneous, involving T cells that secreted type 1 and type 2 cytokines.
摘要
近期的临床试验表明，新一代无细胞百日咳疫苗可提供针对百日咳的保护。然而，接种疫苗诱导的针对百日咳博德特氏菌感染的保护性免疫机制仍有待确定。我们检测了接种一系列无细胞和全细胞百日咳疫苗的儿童的细胞免疫反应。用强效全细胞疫苗免疫儿童可诱导出分泌γ干扰素（IFN-γ）但不分泌白细胞介素-5（IL-5）的百日咳博德特氏菌特异性T细胞。相比之下，接种无细胞百日咳疫苗的儿童的T细胞在体外用百日咳博德特氏菌抗原刺激后会分泌IFN-γ和/或IL-5。这些观察结果表明，全细胞疫苗赋予的保护性免疫，如同天然免疫一样，由1型T细胞介导，而无细胞疫苗产生的免疫保护机制可能更为多样，涉及分泌1型和2型细胞因子的T细胞。
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本文引用的文献
1
A randomized double-blind trial comparing a two-component acellular to a whole-cell pertussis vaccine in Senegal.在塞内加尔进行的一项随机双盲试验，比较双组分无细胞百日咳疫苗与全细胞百日咳疫苗。
Vaccine. 1997 Oct;15(15):1606-12. doi: 10.1016/s0264-410x(97)00100-x.
2
Bordetella pertussis respiratory infection in children is associated with preferential activation of type 1 T helper cells.儿童百日咳博德特氏菌呼吸道感染与1型辅助性T细胞的优先激活有关。
J Infect Dis. 1997 May;175(5):1246-50. doi: 10.1086/593682.
3
Cell-mediated and antibody responses to Bordetella pertussis antigens in children vaccinated with acellular or whole-cell pertussis vaccines. The Progetto Pertosse-CMI Working Group.接种无细胞或全细胞百日咳疫苗儿童对百日咳博德特氏菌抗原的细胞介导和抗体反应。百日咳项目 - 细胞介导免疫工作组
Arch Pediatr Adolesc Med. 1997 Mar;151(3):283-9. doi: 10.1001/archpedi.1997.02170400069013.
4
Effect of schedule on reactogenicity and antibody persistence of acellular and whole-cell pertussis vaccines: value of laboratory tests as predictors of clinical performance.接种程序对无细胞和全细胞百日咳疫苗反应原性及抗体持久性的影响：实验室检测作为临床效果预测指标的价值
Vaccine. 1997 Jan;15(1):51-60. doi: 10.1016/s0264-410x(96)00112-0.
5
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Infect Immun. 1996 Dec;64(12):5295-301. doi: 10.1128/iai.64.12.5295-5301.1996.
6
Pertussis-specific cell-mediated immunity in infants after vaccination with a tricomponent acellular pertussis vaccine.接种三联无细胞百日咳疫苗后婴儿的百日咳特异性细胞介导免疫
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7
Functional diversity of helper T lymphocytes.辅助性T淋巴细胞的功能多样性。
Nature. 1996 Oct 31;383(6603):787-93. doi: 10.1038/383787a0.
8
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Immunology. 1996 Mar;87(3):372-80. doi: 10.1046/j.1365-2567.1996.497560.x.
9
A controlled trial of a two-component acellular, a five-component acellular, and a whole-cell pertussis vaccine.一项关于双组分无细胞、五组分无细胞和全细胞百日咳疫苗的对照试验。
N Engl J Med. 1996 Feb 8;334(6):349-55. doi: 10.1056/NEJM199602083340602.
10
A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group.两种无细胞百日咳疫苗和一种全细胞百日咳疫苗的对照试验。百日咳项目工作组。
N Engl J Med. 1996 Feb 8;334(6):341-8. doi: 10.1056/NEJM199602083340601.
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