Requena L, Kutzner H, Escalonilla P, Ortiz S, Schaller J, Rohwedder A
Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
Br J Dermatol. 1998 Jan;138(1):161-8. doi: 10.1046/j.1365-2133.1998.02045.x.
Several types of cutaneous lesions have previously been described at the sites of herpes zoster scars. We describe 16 patients with cutaneous lesions which had developed on herpes zoster scars. Biopsies were taken from these lesions, and a polymerase chain reaction assay was used to detect the viral genome in paraffin-embedded specimens. Histopathological findings enabled diagnosis of nonspecific granulomatous dermatitis in five patients, granulomatous vasculitis in two patients, lichen sclerosus in two patients, and pseudolymphoma, keloid, sarcoidal granuloma, granuloma annulare, granulomatous folliculitis, lichen planus and cutaneous Rosai-Dorfman disease, each in one patient. Varicella-zoster virus DNA was not identified in any of the patients. Granulomatous folliculitis, lichen sclerosus and cutaneous Rosai-Dorfman disease have not previously been described in herpes zoster scars, but they are three new cutaneous reaction patterns that may have developed within these scars. Our investigations indicate that the cutaneous reactions appearing in herpes zoster scars are not due to the persistence of varicella-zoster virus DNA within the lesions.
先前已描述过带状疱疹瘢痕部位出现的几种类型的皮肤病变。我们描述了16例在带状疱疹瘢痕上出现皮肤病变的患者。从这些病变处取活检组织，并采用聚合酶链反应检测石蜡包埋标本中的病毒基因组。组织病理学检查结果显示，5例患者诊断为非特异性肉芽肿性皮炎，2例患者为肉芽肿性血管炎，2例患者为硬化性苔藓，1例患者分别诊断为假性淋巴瘤、瘢痕疙瘩、结节病样肉芽肿、环状肉芽肿、肉芽肿性毛囊炎、扁平苔藓和皮肤Rosai-Dorfman病。所有患者均未检测到水痘-带状疱疹病毒DNA。肉芽肿性毛囊炎、硬化性苔藓和皮肤Rosai-Dorfman病此前未在带状疱疹瘢痕中被描述过，但它们是可能在这些瘢痕内形成的三种新的皮肤反应模式。我们的研究表明，带状疱疹瘢痕中出现的皮肤反应并非由于病变内水痘-带状疱疹病毒DNA的持续存在。
